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The function of SIK1 in tumorigenesis. SIK1 is a tumor suppressor gene, which performs a crucial regulatory function in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and affects most cancers mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may also promote cance